Collagen – The Foundation of OSSIX^® Brand

The Essential Role of Collagen in Tissue Support

Collagen, derived from the Greek word for “glue,” is the cornerstone of connective tissue in all multicellular organisms.¹ It forms the structural backbone of various tissues and organs, including bones, tendons, cartilage, skin, blood vessels, teeth, cornea, intervertebral disks, and more.^1-3

Collagen’s primary role is to provide mechanical strength and support to tissues, ensuring that organs retain their shape and function even under stress. ^1-3 It acts as a biological scaffold, holding cells together in cohesive units and preventing tissues from tearing or losing shape during movement.^1-3 Additionally, collagen plays a vital regulatory role in developing tissues, guiding the growth and differentiation of cells. ^1-3

The protein’s unique triple-helix structure and its conserved amino acid sequence across species have made it a fundamental component of tissue architecture. To date, over fifteen types of collagen have been identified, each specialized to meet the needs of different tissues.^1-3

Types of Collagen and Their Specific Functions^1-3

• Type I Collagen: The primary collagen in skin, tendons, and bones, providing tensile strength.
• Type II Collagen: Found exclusively in cartilage, ensuring smooth joint function and shock absorption.
• Type III Collagen: Present in the skin, blood vessels, and internal organs, offering elasticity and support.
• Type V Collagen: Essential for the structural integrity of bones, skin, tendons, ligaments, and the cornea.
• Types IV and VIII Collagen: Form critical network structures in basement membranes, supporting cell layers.

OSSIX^® Products: Harnessing Collagen’s Power for Dental Regeneration

OSSIX^® products are leveraging the natural properties of collagen types I & III to deliver high quality products for guided bone and tissue regeneration.^4-6,9-14 By utilizing collagen’s intrinsic qualities, OSSIX^® products offer dental professionals a powerful tool for enhancing patient care.

The OSSIX^® Advantage: Enhanced Collagen Cross-Linking and Controlled Degradation

Collagen in the body undergoes two essential processes—cross-linking and degradation—which are key to its functionality and longevity.^1-3

OSSIX^® products are engineered to optimize these processes by featuring an advanced ribose cross-linking technology that significantly extends their functional lifespan.⁶ Collagen cross-linking occurs through two mechanisms: enzymatic processes and non-enzymatic glycation.^1-3

Non-Enzymatic Glycation: In this natural process, sugars like glucose cross-link collagen, increasing tissue stiffness and durability. ^1-3 OSSIX^® products mimic this natural glycation process, enhancing the mechanical strength and longevity of the collagen-based portfolio. This means that OSSIX^® products provide sustained support throughout the healing process, ensuring that the regenerating tissue is well-protected and reinforced while new bone is forming. ^4-6,9-14

Collagen Degradation Process

Naturally, collagen is degraded in two steps: first by collagenases, which split the triple helix, and then by gelatinases and other enzymes that break down the collagen into absorbable fragments. ^1-3

OSSIX^® products are specifically designed to resist premature degradation, maintaining their structural integrity long enough to fully support the regeneration of bone and tissue^4-6,9-14. This controlled degradation is perfectly timed to align with the body’s natural healing processes, maximizing the effectiveness of the treatment and leading to enhanced clinical outcomes.

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Full list of referencesReferences
1. Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil1, Prashant Munde. Enigmatic insight into collagen. Journal of Oral and Maxillofacial Pathology, 2016. Vol 20. Issue 2.
2. Nimni ME, ed. Collagen: Volume I: Biochemistry. CRC Press; 1988. ISBN 9781315891699.
3. Nimni ME, ed. Collagen: Volume II: Biochemistry and Biomechanics. CRC Press; 1988. ISBN 9781315891682.
4. Smukler, H., D. Capri, and L. Landi, Harvesting bone in the recipient sites for ridge augmentation. Int J Periodontics Restorative Dent, 2008. 28(4): p. 411-9.
5. Takai, Y., et al., Retrospective Case Series Analysis to Evaluate Ridge Augmentation Procedure Applied to Immediate Implant Placement in the Esthetic Zone: Five-Year Longitudinal Evaluation Using Cone Beam Computed Tomography. The International Journal of Periodontics & Restorative Dentistry, 2017. 37: p. 521–530.
6. Levin BP, Rubinstein S., Simultaneous Crestal Sinus Elevation and Implant Placement Using a Ribose Cross-Linked, Collagen Bone Graft Material: Case Series of 28 Consecutive Patients; Compend Contin Educ Dent. 2020;41(3).
7. Data on file. (Animal Study)
8. Data on file. (Safety Evaluation)
9. Tal H, Kozlovsky A, Artzi Z, Nemcovsky CE, Moses O. Long-term bio-degradation of cross-linked and non-cross-linked collagen barriers in human guided bone regeneration. Clin Oral Implants Res. 2008 Mar;19(3):295-302. doi: 10.1111/j.1600-0501. 2007. 01424.x. Epub 2008 Jan 7.
10. Abundo, R., A. Di Domenico, and M. Perelli, Buccal tissue augmentation with a sugar cross‐linked collagen matrix: a case series study (#PR9XH2). Clin Oral Implants Res, 2020. 31(S20): p. 151-151.
11. Casarez-Quintana A, et al (2022). Comparing the histological assessment following ridge preservation using a composite bovine-derived xenograft versus an alloplast hydroxyapatite-sugar cross-linked collagen matrix. Journal of periodontology, 2022;1–10.
12. Zubery Y, Goldlust A, Alves A, and Nir E. (2007). Ossification of a Novel Cross-Linked Porcine Collagen Barrier in Guided Bone Regeneration in Dogs. Journal of Periodontology, 78(1), 112–121.
13. Heather R. Hong et al. (2018) Ridge preservation procedures revisited: A randomized controlled trial to evaluate dimensional changes with two different surgical protocols, Journal of Periodontology, Volume 90, Issue4.
14. Tavelli L, Barootchi S, Rodriguez MV, Meneghetti PC, Mendonça G, Wang HL. Volumetric Outcomes of Peri-implant Soft Tissue Augmentation with a Xenogeneic Cross-Linked Collagen Scaffold: A Comparative Clinical Study. Int J Periodontics Restorative Dent. 2023 Jul-Aug;43(4):415-422.
15. Data on file. (User Feedback Survey)