GLYMATRIX® Technology
Empowering Nature with Advanced Science
for Guided Bone (GBR) and Tissue (GTR) Regeneration
GLYMATRIX® technology is at the heart of OSSIX® products, driving innovation in guided bone regeneration (GBR) and guided tissue regeneration (GTR). 1-8 The technology is inspired by the natural collagen cycle in our bodies, specifically through a biochemical process called glycation.9-10 By mimicking this process, GLYMATRIX® enables the development of advanced regenerative solutions that are highly effective and biocompatible1.
Clinically Proven and Globally Recognized
The efficacy and reliability of GLYMATRIX® are backed by over 100 scientific publications and clinical experience across hundreds of thousands of procedures worldwide. This technology is the result of extensive research dedicated to optimizing glycation as a collagen cross-linking mechanism.9-10
The Science Behind GLYMATRIX®
GLYMATRIX® technology utilizes naturally occurring, nontoxic sugars to cross-link collagen molecules, creating a stable and resilient collagen matrix. 9-10 This matrix forms the foundation of OSSIX® regenerative solutions, each tailored to meet specific clinical needs:
- OSSIX™ Bone: A collagen sponge that promotes bone formation without leaving remnants, ensuring vital bone regeneration.2
- OSSIX® Plus: A resorbable membrane3 that resists degradation even when exposed4, providing long-term protection and support.5
- OSSIX® Volumax: An ossifying, volumizing collagen scaffold6 designed to increase tissue volume7 and support natural bone formation with no residual graft material properties.8
- OSSIX™ Agile: An innovative pericardium membrane specifically engineered for GBR and GTR procedures, offering both flexibility and strength.1
Tailored Bioprogrammability for Optimal Performance
One of the key advantages of GLYMATRIX® technology is its bioprogrammability1, allowing for the creation of biomaterials with precisely engineered stability and properties. The cross-linked collagen matrix developed through GLYMATRIX® not only mimics the look and feel of natural tissue but also performs like it, ensuring that the regenerative materials act as a natural extension of the body’s own biological processes.1-8
Full list of referenceReferences
1. Data on file
2. Casarez-Quintana A, et al (2022). Comparing the histological assessment following ridge preservation using a composite bovine-derived xenograft versus an alloplast hydroxyapatite-sugar cross-linked collagen matrix. Journal of periodontology, 2022;1–10.
3. Tal H, Kozlovsky A, Artzi Z, Nemcovsky CE, Moses O. Long-term bio-degradation of cross-linked and non-cross-linked collagen barriers in human guided bone regeneration. Clin Oral Implants Res. 2008 Mar;19(3):295-302. doi: 10.1111/j.1600-0501. 2007. 01424.x. Epub 2008 Jan 7.
4. Hong HR, Chen C-Y, Kim DM, and Machtei EE. (2018). Ridge preservation procedures revisited: a randomized controlled trial to evaluate dimensional changes with two different surgical protocols. Journal of Periodontology
5. Zubery Y, Goldlust A, Alves A, and Nir E. (2007). Ossification of a Novel Cross-Linked Porcine Collagen Barrier in Guided Bone Regeneration in Dogs. Journal of Periodontology, 78(1), 112–121.
6. Evaluation Of OSSIX® Bone – A Dental Bone Graft Material – and Evaluation of OSSIX® Extend – A Dental Barrier Membrane – In a Beagle Mandibular Guided Bone Regeneration Model. 3 Dec 2015
7. Tavelli L, Barootchi S, Rodriguez MV, Meneghetti PC, Mendonça G, Wang HL. Volumetric Outcomes of Peri-implant Soft Tissue Augmentation with a Xenogeneic Cross-Linked Collagen Scaffold: A Comparative Clinical Study. Int J Periodontics Restorative Dent. 2023 Jul-Aug;43(4):415-422.
8. Neiva R. Evolution of biomaterials in implant dentistry leads toenhanced tissue quality. Compend Contin Educ Dent. 2022;43(7): 454-455.
