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OSSIX® Plus must not be used in patients with known collagen hypersensitivity, sensitivity to porcine-derived materials, or suffer from autoimmune diseases and connective tissue diseases. As the membrane is of a collagen origin, allergic reactions may not be entirely excluded. Please read IFU before use and for additional information on indications, contraindications, warnings and precautions.
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Ossification of a collagen membrane cross-linked by sugar: a human case series

Zubery Y, Nir E, Goldlust A. J Periodontol. 2008;79(6):1101-1107. doi:10.1902/jop.2008.070421

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