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OSSIX® Plus must not be used in patients with known collagen hypersensitivity, sensitivity to porcine-derived materials, or suffer from autoimmune diseases and connective tissue diseases. As the membrane is of a collagen origin, allergic reactions may not be entirely excluded. Please read IFU before use and for additional information on indications, contraindications, warnings and precautions.text text
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Cross-linked and non-cross-linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat

Tal H, Kozlovsky A, Artzi Z, Nemcovsky CE, Moses O.  Clin Oral Implants Res. 2008;19(8):760-766. doi:10.1111/j.1600-0501.2008.01546.x.

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