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OSSIX® Plus must not be used in patients with known collagen hypersensitivity, sensitivity to porcine-derived materials, or suffer from autoimmune diseases and connective tissue diseases. As the membrane is of a collagen origin, allergic reactions may not be entirely excluded. Please read IFU before use and for additional information on indications, contraindications, warnings and precautions.
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Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat

Rothamel D, Schwarz F, Sager M, Herten M, Sculean A, Becker J. Clin Oral Implants Res. 2005;16:369-378. doi:10.1111/j.1600-0501.2005.01108.x

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