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OSSIX® Plus must not be used in patients with known collagen hypersensitivity, sensitivity to porcine-derived materials, or suffer from autoimmune diseases and connective tissue diseases. As the membrane is of a collagen origin, allergic reactions may not be entirely excluded. Please read IFU before use and for additional information on indications, contraindications, warnings and precautions.
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Bone grafting: history, rationale, and selection of materials and techniques

Horowitz RA, Leventis MD, Rohrer MD, Prasad HS. Compend Contin Educ Dent. 2014;35(4):1-6.

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